While Tony Stonem caused mayhem in the first series, a brain bleed in the second left him a more vulnerable character.
Now a fully-fledged star, the 27-year-old is very much part of the Brit pack currently wowing Hollywood.
Ten years on, the fresh-faced actors who played out such dramatic storylines are all grown up, with much of original cast list now mingling with A-list film stars for a living.
It was announced yesterday that Dev Patel, who played hard-partying Anwar Kharral, has been nominated for an Oscar for his most recent role in Hollywood tearjerker Lion, while Nicholas Hoult and Jack O'Connell are both on their way to becoming household names. The Skins cast back in 2008, when they were enjoying their first taste of fame (Pictured from left: Aimee-Ffion Edwards, Larissa Wilson, Joseph Dempsie, Daniel Kaluuya, Dev Patel and Nicholas Hoult )Set in Bristol and written by father-and-son duo Bryan Elsley and Jamie Brittain, Skins documented life for a group of hormone-raging teenagers going through Sixth Form.
Chris Miles' demise, via a brain haemorrhage - the same condition that had killed his older brother, was one of Skins' most poignant moments.
This week April Pearson, who played Michelle Richardson, posted images of her old cast-mates on Instagram, saying: 'I was so lucky and none of us knew how being part of something so special would change our lives. They were the best of times.'Below, we look at the show's breakout stars and how their careers blossomed after the series finished.
When controversial teen drama Skins burst onto television screens via E4 on January 25th 2007, it quickly made a huge impact.
Serving up challenging subjects including eating disorders, drugs and bullying along with a side portion of good old fashioned teen angst, the show had garnered a cult following by the end of the first series.
Alexander Arnold burst onto our screens in his acting debut as Rich Hardbeck in the third generation of Skins.
The 24-year-old has since gone on to star in two-part drama A Mother's Son and in zombie drama In The Flesh.
Skins wasn't Hoult's first major role; he'd already won hearts as the unusually-fringed central protagonist in About a Boy, starring opposite Hugh Grant in the 2002 hit film.